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Researchers Finally Link Long Covid 'Brain Fog' to Inflammation

An anonymous reader shared this report from The Hill: A new study indicates the debilitating "brain fog" suffered by millions of long COVID patients is linked to changes in the brain, including inflammation and an impaired ability to rewire itself following COVID-19 infection. United Press International reported this week that the small-scale study, conducted by researchers at Corewell Health in Grand Rapids, Michigan, and Michigan State University, shows that altered levels of a pair of key brain chemicals could be the culprit. The study marks the first time doctors have been able to provide scientific proof that validates the experiences of the approximately 12 million COVID "long-haulers" in the U.S. who have reported neurological symptoms. Researchers looked at biomarkers in study participants and found that those complaining of brain fog had higher levels of an anti-inflammatory protein that is crucial to regulating a person's immune system, UPI reported. They also showed lower serum levels of nerve growth factor, a protein vital to the brain's plasticity... One of the biggest issues involving long COVID has been doctors' inability to find physical proof of the symptoms described by patients. The study has changed that, according to co-author Dr. Bengt Arnetz.

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The Most Promising Ways to Destroy 'Forever Chemicals'

"Researchers are seeking a breakthrough in technologies to tackle PFAS contamination," reports the Washington Post — including experiments with ultraviolet light, plasma and sound waves: "We're in a good spot," said Christopher Higgins, a professor of civil and environmental engineering at the Colorado School of Mines who researches PFAS. "There's a lot of things being tested. ... Around the world, everyone is trying to work on this topic...." PFAS destruction technologies are beginning to show potential. Some methods have been licensed by companies that are rolling out the systems in real-world settings. "There's been a lot of research happening over the past few years looking at advanced destruction technologies, and there's been a lot of improvements and advancements, and we're now starting to see some of them actually at scale," said Anna Reade [a senior scientist and director of PFAS advocacy at the Natural Resources Defense Council]. An approach known as supercritical water oxidation is one of the more developed technologies, Reade and other experts said. It involves heating and pressurizing water to a specific point that creates the ideal conditions to break every carbon fluorine bond, said Amy Dindal [a PFAS expert with Battelle, a science and technology nonprofit that has developed a PFAS destruction technology]. The process used in a patented technology created by Battelle produces carbon dioxide and a form of fluorine that can be quickly neutralized to become a harmless salt. "It's a complete destruction and mineralization technology, because we're actually breaking all of the carbon fluorine bonds," Dindal said, adding that the technology is "PFAS agnostic...." Another promising approach using heat and pressure was developed by researchers at the Colorado School of Mines [and already licensed by a company in Washington]. Known as hydrothermal alkaline treatment, or HALT, it involves adding a low-cost chemical reagent such as sodium hydroxide to superheated liquid water.... A destruction method that harnesses ultraviolet light has also emerged as a contender [has licensed by a company in Michigan]. When UV light oxidizes an electron-generating compound, it produces a powerful electron that's very reactive and strong enough to break carbon fluorine bonds... Other technologies are experimenting with the use of plasma, which can generate reactive electrons to break down PFAS but tends to require a large amount of energy. Researchers are also experimenting with a process that uses sound waves. High-intensity sound waves create small bubbles in a water system or liquid waste stream, Higgins said. As those bubbles collapse, they can generate the high temperatures and pressure needed to degrade PFAS. But "At the end of the day, not using these chemicals unless it's absolutely necessary is the actually most effective tool in our toolbox," Reade said.

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